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A Special Receptor on Cells Evolved to Protect Mammals from Developing Allergies and Asthma

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FINDING HELPS EXPLAIN HOW ALLERGIC SENSITIVITY ORIGINATES AND SUGGESTS NEW TARGETS FOR ALLERGY AND ASTHMA DRUGS

A special receptor on cells that line the sinuses, throat, and lungs evolved to protect mammals from developing a range of allergies and asthma, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health.

The scientists found that the receptor, dectin-1, recognizes a protein found in house dust mites, cockroaches, shellfish and other invertebrates, and responds by suppressing immune reactions to these common triggers of allergy and asthma. The scientists also found evidence that this protective mechanism is dramatically impaired in people who have asthma or chronic sinusitis due to dust-mite sensitivity.

“Everyone is exposed to these substances, yet most don’t have allergic responses to them, and this mechanism we’ve discovered appears to explain why,” says study senior author Marsha Wills-Karp, PhD, Anna M. Baetjer Professor in Environmental Health at the Bloomberg School and chair of the Department of Environmental Health and Engineering.

The finding, which was published online February 23 in Science Immunology, suggests there may be new ways to treat or prevent allergies and asthma, which afflict tens of millions of people in the U.S. alone. The discovery also hints that while dectin-1 protects against dust-mite and other invertebrate-related allergic responses, there may be additional, undiscovered receptors that suppress allergic responses to pollens and other airborne and dietary allergens.

Dectin-1 previously has been studied as a receptor that recognizes structures on fungi and other microbes and triggers immune responses to them. There have even been suggestions that dectin-1 helps trigger allergic responses to dust mites. To investigate, Wills-Karp and colleagues, including postdoctoral researcher Naina Gour, Ph.D., and assistant scientist Stephane Lajoie, Ph.D., who were first authors of the study, studied mice that were genetically engineered to lack dectin-1.

The researchers found to their surprise that the airways of these dectin-1-deficient mice were more prone to inflammation after exposure to dust mites compared to otherwise identical mice whose airway cells expressed dectin-1 normally. Blocking dectin-1 with antibodies had the same allergy-promoting effect. Thus, dectin-1 protects against dust-mite allergies rather than promoting them.

The scientists determined that dectin-1, in addition to its fungus- and other pathogen-detecting duties, directly recognizes a protein called tropomyosin that is found in house dust mites and other invertebrates. Tropomyosin has previously been implicated as a possible trigger for asthma and shrimp allergies.

The experiments indicated that when dectin-1 recognizes tropomyosin in house dust mites, shrimp or other common allergy-triggering species it suppresses airway cells’ production of an immune molecule, IL-33, which otherwise would promote an allergic response by immune cells.

Underscoring the relevance to humans, the researchers studied nasal and bronchial cells from people who suffer from asthma or chronic rhinosinusitis (nasal congestion/sniffles) due to dust-mite sensitivity and found that on average these cells had a markedly lower expression of the dectin-1 gene. The team also examined data from a prior genetic study of children with asthma and found that a variant of the dectin-1 gene—which reduces production of the receptor—is strongly linked to increased asthma risk.

“Our findings suggest that people who have sufficient dectin-1 in the cells that line their airways won’t experience an allergic response when exposed to airborne dust mites or related allergens—but people with a defect in dectin-1 expression will lack this protection,” Wills-Karp says.

The findings point to the possibility of boosting dectin-1 levels, or otherwise restoring its protective effect, as a new therapeutic strategy against asthma and allergies that are related to dust mites, shrimp or other invertebrate triggers.

The study showed that dectin-1 does not recognize pollens, another major source of allergies. However, Wills-Karp expects that other receptors on airway cells recognize these ubiquitous plant-derived allergens and she hopes to find them in future research.

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Parents, Kids Spend More Time Discussing How To Use Mobile Technology Than Talking About Content

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ANN ARBOR—Most parents would agree that one of the of the biggest modern parenting challenges is monitoring a child’s online activity.

A new study appearing in the Journal of Child and Family Studies found that parents spend more time talking with kids about the mechanics of using their mobile devices than they do about what their kids watch and download on those devices.

The findings came from a small, recent study of 75 children and their families, led by researcher Sarah Domoff, then a postdoctoral fellow at University of Michigan Center for Human Growth and Development. The children wore recording devices at home, which recorded talking, conversations or other sounds nearby, as well as audible screen media use.

Domoff, now an assistant professor at Central Michigan University, said the findings revealed some concerning trends in how families and children communicate about media today. Specifically, the researchers observed minimal conversation about the content of programming that children were watching.

Additionally, they learned that other family members appear to play an important role when content is discussed. Children––not parents––initiated most conversations about content, and older siblings played a much bigger role than parents in content mediation for younger siblings. Also, the study found that children as young as toddlers were exposed to multiple media sources at one time, or media multitasking.

Other findings include:

  • Negotiations and conflict are common among parents and children.
  • Parallel family media use is common, meaning different family members use their own devices at the same time.

“One of the most challenging aspects of parenting today is being aware of what children are exposed to online, particularly content delivered via mobile devices,” Domoff said.

“Thus, it is critical that parents utilize privacy settings and restrictions to protect children from certain content. Ideally, this would occur before the child received their own mobile device.”

Domoff recommends developing a family media plan. In 2016, The American Academy of Pediatrics released a tool that helps families set different goals and media use rules based on individual needs, she said.

It’s also troubling that some apps downloaded by children include advertising or request in-app purchases, she said. Parents can identify these apps by using Common Sense Media’s app review.

Parents can also recruit older children to help younger siblings make good content choices.

The study aimed to identify themes of parental mediation and family communication around mobile media devices. There’s a dearth of scientific data in this area compared to television and video games, but studies show that parental mediation leads to better outcomes for children.

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Internet Therapy Apps Reduce Depression Symptoms

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BLOOMINGTON, Ind. — In a sweeping new study, Indiana University psychologists have found that a series of self-guided, internet-based therapy platforms effectively reduce depression.

The work, which reviewed 21 pre-existing studies with a total of 4,781 participants, was published in the November issue of the Journal of Medical Internet Research. The study was led by Lorenzo Lorenzo-Luaces, an assistant professor of clinical psychology in the IU Bloomington College of Arts and Sciences’ Department of Psychological and Brain Sciences.

In the past several years, many internet-based apps and websites have made claims to treat depression. The subjects of the IU study were specifically those applications that provide treatment with cognitive behavioral therapy, a form of psychotherapy that focuses on changing thought patterns and behavior to alleviate symptoms of depression and other mental disorders.

Previous studies had examined the effectiveness of individual internet-based cognitive behavioral therapy apps, or iCBT, using a range of methods. Until this study, however, no review had examined whether the effects of these treatments were inflated by excluding patients with more severe depression or additional conditions such as anxiety or alcohol abuse.

“Before this study, I thought past studies were probably focused on people with very mild depression, those who did not have other mental health problems, and were at low risk for suicide,” Lorenzo-Luaces said.

“To my surprise, that was not the case. The science suggests that these apps and platforms can help a large number of people.”

For Lorenzo-Luaces, internet-based cognitive behavioral therapy apps are an important new tool for addressing a major public health issue: that individuals with mental health disorders like depression far outnumber the mental health providers available to treat them.

“Close to one in four people meet the criteria for major depressive disorder,” he said.

“If you include people with minor depression or who have been depressed for a week or a month with a few symptoms, the number grows, exceeding the number of psychologists who can serve them.”

People with depression are also expensive for the health care system, he added.

“They tend to visit primary-care physicians more often than others,” Lorenzo-Luaces said.

“They have more medical problems, and their depression sometimes gets in the way of their taking their medication for other medical problems.”

By conducting a “meta-regression analysis” of 21 studies, Lorenzo-Luaces and collaborators decisively determined that internet-based therapy platforms effectively alleviate depression. A central question was determining whether previous studies distorted the strength of these systems’ effects by excluding people with severe depression.

The conclusion was that the apps worked in cases of mild, moderate and severe depression.

Many of the studies in the analysis compared use of internet-based cognitive behavioral therapy apps to placement on a wait list for therapy or the use of a “fake app” that made weak recommendations to the user. In these cases, the iCBT apps worked significantly better.

“This is not to say that you should stop taking your medication and go to the nearest app store,” added Lorenzo-Luaces, who said both face-to-face therapy and antidepressants may still prove to be more effective than the iCBT apps alone.

“People tend to do better when they have a little bit of guidance,” he said. But he added that a 10- to 15-minute check-in may be sufficient for many people, freeing health care providers to see more patients.

App-based therapy also has an advantage in situations where access to face-to-face therapy is limited due to logistical barriers, such as long distances in rural areas or inflexible work schedules.

“ICBT apps take the methods we have learned and make them available to the many people who could benefit from them,” Lorenzo-Luaces said.

“It’s an exciting development.”

 

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New Study Finds Employee Incentives Can Lead To Unethical Behavior In The Workplace

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Considering end-of-year bonuses for your employees? Supervisors be forewarned, a new study finds that while incentive rewards can help motivate and increase employee performance it can also lead to unethical behavior in the workplace.

“Goal fixation can have a profound impact on employee behavior, and the damaging effects appear to be growing stronger in today’s competitive business landscape,” says Bill Becker, co-author of the study and associate professor of management in the Pamplin College of Business at Virginia Tech.

The study, “The effects of goals and pay structure on managerial reporting dishonesty,” provides valuable insight into the relationship between pay structures and motivation.

Findings suggest that setting compensation goals can increase dishonesty when managers are also paid a bonus for hitting certain targets.

“These unintended negative consequences can lead to dishonesty, unethical behavior, increased risk-taking, escalation of commitment, and depletion of self-control,” says Becker.

The study points to observations of unethical behaviors in the workplace that include employees falsifying or manipulating financial reporting information as well as time and expense reports.

For example, service professionals such as auditors, contractors, lawyers, and consultants who report hours billed against a target budget is often based on a fixed contract price.

“This causes potential for both under-reporting and over-reporting costs, which can undermine organizational objectives and negatively impact the interest of the firm,” says Becker.

“Using purely monetary incentives is almost always a double edged sword.”

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